Light Microscopy Specialist
As a Light Microscopy Specialist in the Biophotonics Core Facility at the Salk Institute, Jamie Kasuboski's primary responsibility is the training of new users in cutting-edge microscopy and imaging techniques as well as data analysis methods. Jamie is a cell biologist by doctoral training and in his Ph.D. he focused on examining the roles that mitotic genes and kinases play in the regulation of mitosis and their implications in cancer development. Specifically, this detail-oriented work focused on characterizing anticancer therapeutics and identifying their mechanisms of action. The success of this project required the development novel fluorescence assays for determining protein localization in fixed and live specimens. Ultimately, this work revealed unique and novel insights into the genes required for proper cell division and identified several new drug targets for potential cancer therapies.
- B.S. in Biology with minor in Chemistry, Hillsdale College, Hillsdale, MI, USA
- Ph.D. in Cellular and Molecular Biology, University of Notre Dame, Notre Dame, IN, USA
Awards and Honors
- Notre Dame Research Fellowship (2006 and 2011)
- Howard and Patricia York Graduate School Fellowship (2010)
- L. Crabbe, A.J. Cesare, J.M. Kasuboski, J.A.J. Fitzpatrick, and J. Karlseder. 2012. Human telomeres are tethered to the nuclear envelope during postmitotic nuclear assembly. Cell Reports. Dec 27;2(6):1521-9.
- J.M. Kasuboski, Y.J. Sigal, M.S. Joens, B.F. Lillemeier and J.A.J. Fitzpatrick. 2012. Invited Chapter on "Super-Resolution Microscopy: a comparative treatment" Current Protocols in Cytometry. Oct; Chapter 2: Unit 2.17.
- J Kasuboski, J Bader, S Tauhata, M Joyce, M Winding, M Morrissey, G Chan, P.S. Vaughan and K.T. Vaughan. 2011. Phosphorylation of Zwint by Aurora B is Required for Recruitment of Cytoplasmic Dynein to Kinetochores. Mol.Bio. Cell. July 20. mbc.E11-03-0213.
- J.R. Bader, J Kasuboski, M Winding, C Zhang, P.S. Vaughan and K.T. Vaughan. 2011. Polo-like Kinase1 is Required for Recruitment of Dynein to Kinetochores During Mitosis. J. Biol. Chem. Jun 10. 286(23):20769-77.
- J Kasuboski, A Wehenkel, S Santaguida, F Çivri, K.T. Vaughan, A Musacchio. 2011. The Role of MPS-1 in Regulation of RZZ Complex Assembly and Kinetochore Recruitment.Cell Science. In preparation.
- C Cole, J Bader, J Kasuboski, P.S. Vaughan and K.T. Vaughan. Spindly Regulates a Subset of Dynein at the Kinetochore.J. Biol. Chem. In preparation.