Salk Institute
Waitt Advanced Biophotonics Core
Andrew Loftus

Andrew Loftus

Light Microscopy Specialist


Biophotonics Core

As a Light Microscopy Specialist in the Biophotonics Core Facility at the Salk Institute, Andrew Loftus’s primary responsibility is the training of new users in cutting-edge microscopy and imaging techniques. Andrew is a Biophysicist by doctoral training. In his Ph.D. he investigated the alteration of the mechanical properties of lipid membranes by Sar1, a vesicle trafficking protein utilizing both optical trapping techniques and fluorescence microscopy. In addition, he also explored how peptide and protein conjugates to multi-arm polymers altered membrane mechanics and used light sheet microscopy to monitor the fluctuations of giant vesicles and measure membrane rigidity. Andrew also worked as an intern at Life Technologies where he was embedded in the QuantumDot product team working on developing and testing new bio-conjugation techniques for cellular marker products.

Education

  • B.S. in Chemistry, University of Virginia, Richmond, VA, USA
  • Ph.D. in Biophysics, University of Oregon, Eugene, OR, USA

Awards and Honors

  • National Science Foundation - IGERT Fellowship, 2010-11
  • Jean Dreyfus Boissevain Undergraduate Scholarship for Excellence in Chemistry, 2007
  • Howard Hughes Medical Institute Scholar, 2005 and 2006

Selected Publications

  • A.F. Loftus, S. Noreng, V. Hsieh and R. Parthasarathy. 2013. Robust measurement of membrane bending moduli using light sheet fluorescence imaging of vesicle fluctuations. Langmuir, 29, 14588-14594.
  • A.F. Loftus, V Hsieh and R Parthasarathy. Modulation of membrane rigidity by the human vesicle trafficking proteins Sar1A and Sar1B. 2012. Biochemical and Biophysical Research Communications, 426, 585-589.
  • I. Settles*, A.F. Loftus*, A. McKeown and R. Parthasarathy. 2010. The Vesicle Trafficking Protein Sar1 Lowers Membrane Rigidity. Biophysical Journal, 99, 1539-45. *co-first authors.
  • A.F. Loftus, K. Reighard, S. Kapourales and M.C.Leopold. 2008. Monolayer-Protected Nanoparticle Film Assemblies as Platforms for Controlling Interfacial and Adsorption Properties in Protein Monolayer Electrochemistry. Journal of the American Chemical Society, 130, 1649-61.
  • D. J. Tognarelli, R.B. Miller, R.R. Pompano, A.F. Loftus, D.J. Sheibley, and M.C. Leopold. 2005. Covalently Networked Monolayer-Protected Nanoparticle Films. Langmuir, 21, 11119.

 

 

 


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